Liver Metastasis: Biology and Clinical Management - natural-aloevera.ro

Metastatic cancer of the liver treatment, Colorectal cancer with liver metastases treatment, REVISTA FARMACIA

Conținutul

    Abstract Aim: Malignant tumors localized in the digestive tract have a tendency to local growth and invasion with lymph node metastasis. Distant metastases through blood with prevalent liver location are detected late in disease progression, in an advanced stage, when therapeutic possibilities are often limited to palliative therapy. Material and methods: The study included a series of patients with liver metastases admitted to the Center of Gastroenterology and Hepatology Iasi between January 1 and October 10, for the identification of primitive tumor.

    While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease.

    To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential.

    Metastatic cancer of the liver treatment When Colorectal Cancer Reaches the Liver hepatic cancer guidelines Abstract Aim: Malignant tumors localized in the digestive tract have a tendency to local growth and invasion with lymph node metastasis. Distant metastases through blood with prevalent liver location are detected late in disease progression, in an advanced stage, when therapeutic possibilities are often limited to palliative therapy. Material and methods: The study included a series of patients with liver metastases admitted to the Center of Gastroenterology and Hepatology Iasi between January 1 and October 10, for the identification of primitive tumor. The patients were investigated by endoscopy, imaging, laboratory tests including tumor markers.

    Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases.

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    Written by metastatic cancer of the liver treatment researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted.

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    In addition, the role of inflammation pre-existing and tumor-inducedhost innate and adaptive immune ce casti sunt în scaun, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases.

    These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities.

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    Cellular and molecular aspects of the liver architecture and function. The tumor microenvironment at different stage of hepatic metastasis.

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    Role of CXC chemokines and receptors in liver metastasis — impact on liver resection-induced engraftment and tumor growth. Role of Inflammation in the early stages of liver metastasis.

    Signal transduction in tumor-endothelial cell communication. Tumor dormancy in liver metastasis: clinical and experimental evidence and implications for treatment.

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    Role of the Metastatic cancer of the liver treatment axis in liver metastasis: experimental and clinical evidence. Breast Cancer Liver Metastasis.

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    Imaging of Hepatic Metastases. Proteomic profiling of hepatic metastases: Paving the way to individualized therapy.

    Targeting Angiogenesis in the Treatment of Hepatic Metastasis. Uveal melanoma — a paradigm of site-specific liver metastasis.

    Distant metastases through blood with prevalent liver location are detected late in disease progression, in an advanced stage, when therapeutic possibilities are often limited to palliative therapy. Material and methods: The study included a series of patients with liver metastases admitted to the Center of Gastroenterology and Hepatology Iasi between January 1 and October 10, for the identification of primitive tumor.